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Does Ozempic Make You Tired

Does Ozempic Make You Tired? – Addressing Your Concerns

Has fatigue become a part of your daily routine? Do you have no idea why you’re feeling tired? – Let us help you out!

Have you ever thought if the weight loss medication that you’re taking could be what’s making you feel tired?

Ozempic has emerged as a popular choice in the world of weight loss and diabetes management – But, does Ozempic make you tired?

Join us as we address this commonly reported concern in this blog – Exploring Ozempic in detail, discovering the connection between Ozempic and fatigue, addressing your common queries, and determining if Ozempic fatigue is a real thing.

What is Ozempic?

Ozempic, scientifically known as semaglutide, belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists.

It is primarily used in the treatment of type 2 diabetes, helping to regulate blood sugar levels. This injectable medication mimics the effects of natural GLP-1, which plays a crucial role in glucose metabolism and insulin secretion.

It has also gained popularity as a weight loss medication due to the side effects it offers. It works by reducing hunger, increasing feeling of fullness, and slowing down gastric emptying – a combination of actions that support individuals with weight loss.

Does Ozempic Make You Tired?

Yes! Fatigue is one of the potential side effects of Ozempic. However, it’s important to understand the reasons behind this Ozempic fatigue and whether it’s a common occurrence.

Why Does Ozempic Make You Tired?

To understand the Ozempic tiredness, let’s take a look at its mechanisms and how it interacts with your body.

  • Blood Sugar Regulation: Ozempic helps in regulating blood sugar levels, and as your body adjusts to the medication, it affects glucose utilization, potentially impacting energy levels.
  • Metabolic Shifts: The metabolic changes induced by Ozempic, particularly in the early stages of treatment, can lead to fluctuations in energy.
  • Insulin Sensitivity: By enhancing insulin sensitivity, Ozempic helps your cells utilize glucose more effectively. This leads to alterations in energy distribution, causing temporary fatigue.
  • Individual Variability: People respond differently to medications. Factors such as individual metabolic rates, overall health, and lifestyle can influence how Ozempic affects energy levels. Some individuals may experience fatigue as a side effect, while others may not.

Does Ozempic Fatigue Go Away?

The good news is that Ozempic fatigue is often temporary. Adaptation is a common phenomenon, and as your body adjusts to the medication, the fatigue tends to diminish over time.

How Long Does Ozempic Fatigue Last?

The duration of Ozempic tiredness varies from person to person. While some may experience it only during the initial weeks, others might find that it gradually fades away over a few months.

Side Effects of Ozempic

It is important to be aware of the potential side effects of any medication that has been prescribed. Here’s a list of side effects associated with Ozempic:

  • Nausea and Vomiting: Some individuals may experience mild nausea or occasional vomiting as their bodies adjust to Ozempic.
  • Changes to Your Face (Ozempic Face): “Ozempic face” refers to a fuller facial appearance that can occur due to the medication’s impact on fluid retention.
  • Pancreatitis: While rare, Ozempic has been associated with pancreatitis. If you experience persistent abdominal pain, seek medical attention promptly.
  • Low Blood Sugar: Ozempic’s blood sugar-lowering effects may lead to hypoglycemia, characterized by symptoms like shakiness, sweating, and confusion.
  • Diarrhea or Constipation: Gastrointestinal effects, such as diarrhea or constipation, may occur.
  • Abdominal Pain: Abdominal discomfort is a potential side effect of Ozempic.
  • Kidney Damage: Although rare, Ozempic has also been associated with kidney damage. Regular monitoring is essential for those at risk.
  • Allergic Reactions: In rare cases, individuals may also experience allergic reactions to Ozempic. Seek immediate medical attention if you notice signs like swelling or difficulty breathing.
  • Thyroid Tumors: Studies have suggested a potential link between Ozempic and thyroid tumors as well. Regular thyroid monitoring is recommended when using this medication.
  • Hair Loss: Some individuals may also notice hair loss during Ozempic treatment. This side effect is generally reversible.
  • Rebound Weight Gain: After discontinuing Ozempic, some individuals may experience rebound weight gain. Adopting a healthy lifestyle can mitigate this effect.
  • Headache: Headaches can occur as a side effect. Staying hydrated and managing stress may help alleviate this symptom.
  • Burping: Gastrointestinal effects, including burping, are possible during Ozempic treatment. Adjusting the diet and eating habits may provide relief.
  • Fatigue: Ozempic fatigue is a common side effect, especially during the initial stages of Ozempic treatment. This often resolves as your body adapts to the medication.

How To Treat Ozempic Tiredness?

Ozempic tiredness can be challenging, but the good news is that there are proactive steps you can take to manage this side effect.

Here are effective strategies to treat Ozempic tiredness:

  • Improve Sleep: Adequate and quality sleep is essential for overall well-being. Establish a consistent sleep schedule, create a calming bedtime routine, and ensure your sleep environment is conducive to rest.
  • Focus on Nutrition Diet: A balanced and nutritious diet plays a crucial role in combating Ozempic fatigue. Ensure your meals include a mix of complex carbohydrates, lean proteins, and healthy fats. Stay hydrated throughout the day, and consider smaller, more frequent meals to maintain a steady energy level.
  • Regular Exercise: Incorporating regular physical activity into your routine can combat Ozempic fatigue by significantly boosting energy levels. Engage in activities like brisk walking, cycling, or yoga.
  • Consider Dietary Supplements: Discussing the potential use of dietary supplements with your healthcare provider can be beneficial. Supplements like iron, vitamin B12, and vitamin D are commonly associated with energy levels.
  • Refrain From Alcohol: Alcohol can contribute to dehydration and disrupt sleep patterns, potentially exacerbating Ozempic tiredness. Limiting or refraining from alcohol consumption, particularly in the evening, can positively impact your energy levels and overall health.

When to See a Doctor?

While some side effects are expected during the adjustment period, it’s crucial to consult your healthcare provider if you experience persistent or severe Ozempic fatigue or other symptoms. Seek medical attention if you notice any alarming changes in your health.


When seeking weight loss with Ozempic or effective diabetes management, understanding the medication’s side effects is essential. While Ozempic fatigue does occur initially, it’s often a temporary phase.

At Manhattan Medical Arts, we prioritize your health and well-being. If you have concerns about Ozempic or diabetes management, our team of experienced healthcare professionals is here to guide you at all times – not just with treatment options, but also by ensuring that you have all the needed information to deal with such conditions.

Frequently Asked Questions

Does semaglutide make you tired?

Yes, fatigue is listed as a potential side effect of semaglutide, which is the active ingredient in Ozempic.

What happens if you take too much Ozempic?

Taking too much Ozempic can lead to hypoglycemia (low blood sugar), which may cause symptoms such as shakiness, sweating, and confusion. It’s crucial to follow the prescribed dosage.

How does Ozempic make you feel?

Ozempic can have varied effects on individuals. Some may experience increased energy, while others might initially experience Ozempic tiredness and/or other side effects. It’s essential to monitor how your body responds and communicate any concerns with your healthcare provider.

Does Ozempic help you sleep better?

While Ozempic is not directly prescribed for sleep improvement, its impact on blood sugar levels may indirectly contribute to better sleep in individuals managing diabetes. However, individual responses may vary.

Can Ozempic cause extreme fatigue?

Yes, Ozempic fatigue is a very real side effect of consuming this medication. It’s essential to monitor and communicate any severe or persistent fatigue with your healthcare provider to ensure appropriate management.

– Disclaimer –

This blog is for informational & educational purposes only, and does not intend to substitute any professional medical advice or consultation. For any health related concerns, please consult with your physician, or call 911.

Medically Reviewed

Last reviewed by Dr. Syra Hanif, M.D. on 12/27/2023

Learn more about our editorial process.

  • About The Author

    Dr. Syra Hanif M.D.

    Board Certified Primary Care Physician

Dr. Syra Hanif is a board-certified Primary Care Physician (PCP) dedicated to providing compassionate, patient-centered healthcare.

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